Monitoring the reaction of the body state to antibiotic treatment against helicobacter pylori via infrared spectroscopy: A case study

Kiran Sankar Maiti, Alexander Apolonski

Research output: Contribution to journalArticlepeer-review

Abstract

The current understanding of deviations of human microbiota caused by antibiotic treatment is poor. In an attempt to improve it, a proof-of-principle spectroscopic study of the breath of one volunteer affected by a course of antibiotics for Helicobacter pylori eradication was performed. Fourier transform spectroscopy enabled searching for the absorption spectral structures sensitive to the treatment in the entire mid-infrared region. Two spectral ranges were found where the corresponding structures strongly correlated with the beginning and end of the treatment. The structures were identified as methyl ester of butyric acid and ethyl ester of pyruvic acid. Both acids generated by bacteria in the gut are involved in fundamental processes of human metabolism. Being confirmed by other studies, measurement of the methyl butyrate deviation could be a promising way for monitoring acute gastritis and anti-Helicobacter pylori antibiotic treatment.

Original languageEnglish
Article number3474
JournalMolecules
Volume26
Issue number11
DOIs
Publication statusPublished - 1 Jun 2021

Keywords

  • Acute gastritis
  • Alpha-keto acid
  • Antibiotic treatment
  • Breath
  • Helicobacter pylori
  • Metabolites
  • Mid-infrared spectroscopy
  • Short-chain fatty acid
  • Treatment dynamics: microbiota
  • Volatile organic compound
  • Helicobacter Infections/drug therapy
  • Anti-Bacterial Agents/chemistry
  • Humans
  • Middle Aged
  • Spectrophotometry, Infrared/methods
  • Male
  • Gastritis/drug therapy
  • Helicobacter pylori/drug effects
  • Gastrointestinal Microbiome/drug effects
  • Butyric Acid/chemistry
  • Pyruvic Acid/chemistry
  • Esters/chemistry

OECD FOS+WOS

  • 1.06.CQ BIOCHEMISTRY & MOLECULAR BIOLOGY
  • 3.01 BASIC MEDICAL RESEARCH
  • 1.04 CHEMICAL SCIENCES

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