Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions

Mikhail V. Shaposhnikov, Zulfiya G. Guvatova, Nadezhda V. Zemskaya, Liubov A. Koval, Eugenia V. Schegoleva, Anastasia A. Gorbunova, Denis A. Golubev, Natalya R. Pakshina, Natalia S. Ulyasheva, Ilya A. Solovev, Margarita A. Bobrovskikh, Nataly E. Gruntenko, Petr N. Menshanov, George S. Krasnov, Anna V. Kudryavseva, Alexey A. Moskalev

Research output: Contribution to journalArticlepeer-review

Abstract

Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin, and rapamycin, photodeprivation, and low-temperature conditions up to 185 days in w1118 strain and up to 213 days in long-lived E(z)/w mutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, immune response, and autophagy in the registered effect.

Original languageEnglish
Article number566
JournalCommunications Biology
Volume5
Issue number1
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Aging/physiology
  • Animals
  • Autophagy
  • Drosophila melanogaster/genetics
  • Genotype
  • Longevity/genetics

OECD FOS+WOS

  • 1.06 BIOLOGICAL SCIENCES

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