Modulators of Hematopoiesis Disorders (a Review)

N. F. Salakhutdinov, S. S. Laev, D. S. Sergeevichev

Research output: Contribution to journalReview articlepeer-review

Abstract

Disorders of hematopoiesis caused by the action of various factors (hemotoxic substances, drugs, cytotoxic drugs, radiation) lead to a deviation from the norm and the development of the diseases varying in complexity. The restoration of hematopoiesis under extreme conditions is vital, and the search for the drugs stimulating hematopoiesis is an extremely urgent task. The most interesting agents are low molecular weight compounds that can stimulate hematopoiesis in case of its disorders. The presented literature review discusses various factors leading to hematopoietic disorders, and drugs that have shown sufficient effectiveness in eliminating these disorders, in particular with cytostatic therapy and the treatment of hemolytic pathologies. The review can be useful in the search for agents that stimulate hematopoiesis, and is addressed not only to medical and chemical professionals, but also to a wide range of readers.

Original languageEnglish
Pages (from-to)332-353
Number of pages22
JournalChemistry for Sustainable Development
Volume28
Issue number4
DOIs
Publication statusPublished - 2020

Keywords

  • hematopoiesis
  • bone marrow
  • cytostatic drug
  • hemostimulating activity
  • anemia
  • leukemia
  • ACUTE PROMYELOCYTIC LEUKEMIA
  • TRANS-RETINOIC ACID
  • BONE-MARROW
  • KINASE INHIBITOR
  • RADIATION-INJURY
  • PROGENITOR CELLS
  • IN-VITRO
  • STEM
  • CYCLOPHOSPHAMIDE
  • MELATONIN

OECD FOS+WOS

  • 2.04 CHEMICAL ENGINEERING
  • 1.05 EARTH AND RELATED ENVIRONMENTAL SCIENCES

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