Modern approaches to modification of bile acids for the synthesis of compounds possessing valuable physicochemical and biological properties

Irina I. Popadyuk, Oksana V. Salomatina, Nariman F. Salakhutdinov

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)

    Abstract

    Data published in the period from 2000 to 2015 on chemical transformations of the major human bile acids (cholic, chenodeoxycholic, deoxycholic and lithocholic acids) and ursodeoxycholic acid are integrated and described systematically. Characteristic features of their structures, biosynthesis, main sources and biological functions are considered. The data on chemical transformations of the indicated bile acids include reactions involving modifications of the side chain or the steroid nucleus. The biological activities and applications of these derivatives are surveyed in brief. The bibliography includes 227 references.

    Original languageEnglish
    Pages (from-to)388-443
    Number of pages56
    JournalRussian Chemical Reviews
    Volume86
    Issue number5
    DOIs
    Publication statusPublished - 2017

    Keywords

    • RECEPTOR 1 GP-BAR1
    • PALLADIUM-CATALYZED AMINATION
    • CARBONIC-ANHYDRASE INHIBITORS
    • RING-CLOSING METATHESIS
    • O-IODOXYBENZOIC ACID
    • FARNESOID-X-RECEPTOR
    • ALPHA-AMINO-ACIDS
    • CHOLIC-ACID
    • URSODEOXYCHOLIC ACID
    • IN-VITRO

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