Modelling of the arteriovenous malformation embolization optimal scenario: AVM embolization optimal scenario

Alexandr A. Cherevko, Tatiana S. Gologush, Irina A. Petrenko, Vladimir V. Ostapenko, Vyacheslav A. Panarin

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebral arteriovenous malformation (AVM) is a congenital brain vessels pathology, in which the arterial and venous blood channels are connected by tangles of abnormal blood vessels. It is a dangerous disease that affects brain functioning causing the high risk of intracerebral haemorrhage. One of AVM treatment methods is embolization - the endovascular filling of the AVM vessel bundle with a special embolic agent. This method is widely used, but still in some cases is accompanied by intraoperative AVM vessels rupture. In this paper, the optimal scenario of AVM embolization is studied from the safety and effectiveness of the procedure point of view. The co-movement of blood and embolic agent in the AVM body is modelled on the basis of a one-dimensional two-phase filtration model. Optimal control problem with phase constraints arising from medicine is formulated and numerically solved. In numerical analysis, the monotone modification of the CABARET scheme is used. Optimal embolization model is constructed on the basis of real patients' clinical data collected during neurosurgical operations. For the special case of embolic agent, input admissible and optimal embolization scenarios were calculated.

Original languageEnglish
Article number191992
Number of pages16
JournalRoyal Society Open Science
Volume7
Issue number7
DOIs
Publication statusPublished - 1 Jul 2020

Keywords

  • arteriovenous malformation
  • CABARET scheme
  • haemodynamics
  • optimal control
  • two-phase filtration
  • CABARET SCHEME
  • BLOOD-FLOW
  • NATURAL-HISTORY
  • SIMULATION
  • SCALAR CONSERVATION LAW
  • 3D
  • MATHEMATICAL-MODEL
  • BRAIN

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