Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2′-bipyridine, 1,10-phenanthroline: Synthesis, structure and cytotoxic activity

Julia A. Eremina, Elizaveta V. Lider, Denis G. Samsonenko, Liliya A. Sheludyakova, Alexey S. Berezin, Lyubov S. Klyushova, Vladimir A. Ostrovskii, Rostislav E. Trifonov

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The [Cu2(2,2′-bipy)2(L1)4] (1), [Cu2(1,10-phen)2(L1)4] (2), [Cu(2,2′-bipy)(L2)2]n (3) and [Cu2(1,10-phen)2(L2)4] (4) complexes, where HL1 – 5-phenyltetrazole, and HL2 – 1H-tetrazole, have been synthesized. All complexes have been characterized by elemental analysis, IR, EPR spectroscopy and X-ray diffraction. The complexes possess distorted tetragonal-pyramidal coordination geometry. Compounds 1, 2, 4 show μ-5-phenyl-tetrazole/tetrazole bridged dinuclear structures, while compound 3 reveals polymeric structure. The effect of compounds on viability of the MCF-7 and Hep-2 cell lines was investigated in vitro. The study showed that tetrazole ligands HL1 and HL2 are non-toxic at tested concentrations (1–50 μM), while 1,10-phen and 2,2′-bipy posses cytotoxicity. All of the complexes exhibit significant dose-dependent cytotoxic effect and have the potential to act as efficient cytotoxic drugs. The complexes [Cu(1,10-phen)Cl2] (5) and [Cu(2,2′-bipy)Cl2] (6) have also been obtained to establish the influence of insertion of tetrazole ligands in compounds on their cytotoxic properties.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalInorganica Chimica Acta
Volume487
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • 1,10-Phenanthroline
  • Cytotoxicity
  • Hep-2
  • MCF-7
  • Mixed ligand Cu(II) complexes
  • Tetrazole
  • OXIDATION
  • DNA CLEAVAGE
  • INTERCALATION
  • IN-VITRO
  • CHEMISTRY
  • INHIBITOR
  • BOND

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