Mechanisms of Coronavirus Genome Stability As Potential Targets for Antiviral Drugs

S. K. Yuyukina; D. O. Zharkov

doi:10.1134/S1019331622040256

Mechanisms of Coronavirus Genome Stability As Potential Targets for Antiviral Drugs

Research output: Contribution to journal › Article › peer-review

Abstract

The COVID-19 pandemic has made it necessary to create antivirals active against the SARS-CoV-2 coronavirus. One of the widely used strategies to fight off viral infections is the use of modified nucleoside analogues that inhibit viral replication by incorporating DNA or RNA into the growing chain, thus stopping its synthesis. The difficulty of using this method of treatment in the case of SARS-CoV-2 is that coronaviruses have an effective mechanism for maintaining genome stability. Its central element is the nsp14 protein, which is characterized by exonuclease activity, due to which incorrectly included and noncanonical nucleotides are removed from the 3' end of the growing RNA chain. Inhibitors of nsp14 exonuclease and nucleoside analogues resistant to its action are viewed as potential targets for anticoronavirus therapy.

Translated title of the contribution	Механизмы обеспечения стабильности генома коронавирусов как потенциальные мишени для противовирусных средств
Original language	English
Pages (from-to)	470-478
Number of pages	9
Journal	Herald of the Russian Academy of Sciences
Volume	92
Issue number	4
DOIs	https://doi.org/10.1134/S1019331622040256
Publication status	Published - Aug 2022

Keywords

corrective exonuclease
COVID-19
genome stability
nucleoside inhibitors
replication
RNA-dependent RNA polymerase
SARS-CoV-2

OECD FOS+WOS

1.06 BIOLOGICAL SCIENCES

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title = "Mechanisms of Coronavirus Genome Stability As Potential Targets for Antiviral Drugs",

abstract = "The COVID-19 pandemic has made it necessary to create antivirals active against the SARS-CoV-2 coronavirus. One of the widely used strategies to fight off viral infections is the use of modified nucleoside analogues that inhibit viral replication by incorporating DNA or RNA into the growing chain, thus stopping its synthesis. The difficulty of using this method of treatment in the case of SARS-CoV-2 is that coronaviruses have an effective mechanism for maintaining genome stability. Its central element is the nsp14 protein, which is characterized by exonuclease activity, due to which incorrectly included and noncanonical nucleotides are removed from the 3' end of the growing RNA chain. Inhibitors of nsp14 exonuclease and nucleoside analogues resistant to its action are viewed as potential targets for anticoronavirus therapy.",

keywords = "corrective exonuclease, COVID-19, genome stability, nucleoside inhibitors, replication, RNA-dependent RNA polymerase, SARS-CoV-2",

author = "Yuyukina, {S. K.} and Zharkov, {D. O.}",

note = "Funding Information: This study was supported by the Russian Foundation for Basic Research, project no. 20-04-60433. Publisher Copyright: {\textcopyright} 2022, Pleiades Publishing, Ltd.",

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Mechanisms of Coronavirus Genome Stability As Potential Targets for Antiviral Drugs

Abstract

Keywords

OECD FOS+WOS

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