Mathematical modelling of acute phase of myocardial infarction

Chermen A. Tsgoev, Olga F. Voropaeva, Yuri I. Shokin

Research output: Contribution to journalArticlepeer-review

Abstract

A mathematical model of the dynamics of cardiomyocyte death in myocardial infarction during the acute phase of the disease is developed. An economical computing technology of structural and parametric identification of model equations is presented based on the use of experimental data as dynamic parameters and on the idea of splitting the inverse coefficient problem with a large number of unknown parameters into a sequence of simpler inverse problems. The relevance of the proposed mathematical model is confirmed by comparison of the numerical solution to the problem with experimental data and also with the results of modelling of known therapeutic strategies.

Original languageEnglish
Pages (from-to)111-126
Number of pages16
JournalRussian Journal of Numerical Analysis and Mathematical Modelling
Volume35
Issue number2
DOIs
Publication statusPublished - 28 Apr 2020

Keywords

  • computational technology
  • cytokine therapy
  • inflammation
  • inverse coefficient problem
  • macrophages M1 and M2
  • Mathematical modelling
  • myocardial infarction
  • necrosis
  • structural identification of ODE

Fingerprint Dive into the research topics of 'Mathematical modelling of acute phase of myocardial infarction'. Together they form a unique fingerprint.

Cite this