Mathematical and Numerical Models of the Central Regulatory Circuit of the Morphogenesis System of Drosophila

T. A. Bukharina, A. A. Akinshin, V. P. Golubyatnikov, D. P. Furman

Research output: Contribution to journalArticlepeer-review

Abstract

The results are presented of mathematical and computer simulation of the functioning ofthe central regulatory circuit (CRC) which is the system integrator of the gene networks ofmorphogenesis of Drosophila mechanoreceptors. The main element of the CRC is represented bythe complex of Achaete-Scute (AS-C) genes, the main genes of the mechanoreceptor morphogenesis.The content level of the proteins encoded by the AS-Cgenes is a determining factor for initiating the development of a mechanoreceptor. We carried outa comparative study of the CRC behavior under normal conditions and in the presence ofmutational changes in the Achaete-Scute complex. Theresults of simulation are in good accord with the available biological data.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalJournal of Applied and Industrial Mathematics
Volume14
Issue number2
DOIs
Publication statusPublished - 1 May 2020

Keywords

  • Achaete-Scute complex
  • central regulatory circuit
  • Drosophila
  • gene network
  • mathematical model
  • mechanoreceptor
  • mutation
  • nonlinear dynamical system
  • numerical simulation

Fingerprint Dive into the research topics of 'Mathematical and Numerical Models of the Central Regulatory Circuit of the Morphogenesis System of Drosophila'. Together they form a unique fingerprint.

Cite this