Materials based on X-ray contrast octahedral metal cluster complexes and hydrophilic polymers

Ekaterina V. Svezhentseva, Anton A. Ivanov, Yuri A. Vorotnikov, Svetlana N. Gyrylova, Olga G. Kurskaya, Marina A. Gulyaeva, Alexander Y. Alekseev, Yuri V. Mironov, Michael A. Shestopalov, Alexander M. Shestopalov

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Herein we report the comparative study of cytotoxicity of a series of hexarhenium cluster complexes of general formula [{Re6Q8}L6]n (Q = S, Se, Te; L = P(CH2CH2COO-)3, SO3 2-, OH-, CN-) in the presence of hydrophilic polymers: dextran-70 (Mw ∼70 kDa) and polyethylene glycol (Mw ∼40 kDa) and their oxidised derivatives. It was demonstrated that cluster complexes in the presence of dextran polymers are generally more cytotoxic than non-coated cluster complexes, while PEG-coated cluster complexes are vice versa less cytotoxic.

Original languageEnglish
Pages (from-to)11430-11436
Number of pages7
JournalMaterials Today: Proceedings
Volume4
Issue number11
DOIs
Publication statusPublished - 2017

Keywords

  • Cytotoxicity
  • Hydrophilic polymers
  • Rhenium clusters
  • hydrophilic polymers
  • ANTIBIOTICS
  • rhenium clusters
  • MOLYBDENUM
  • TOXICITY
  • cytotoxicity
  • RHENIUM

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