Magnetic field effect in natural cryptochrome explored with model compound

Shubhajit Paul, Alexey S. Kiryutin, Jinping Guo, Konstantin L. Ivanov, Jörg Matysik, Alexandra V. Yurkovskaya, Xiaojie Wang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Many animals sense the Earth's magnetic-field and use it for navigation. It is proposed that a light-dependent quantum effect in cryptochrome proteins, residing in the retina, allows for such an iron-free spin-chemical compass. The photochemical processes, spin-dynamics and its magnetic field dependence in natural cryptochrome are not fully understood by the in vivo and in vitro studies. For a deeper insight into these biophysical mechanisms in cryptochrome, we had introduced a flavin-tryptophan dyad (F10T). Here we present the magnetic field dependence of 1H photo-CIDNP NMR on F10T and a theoretical model for low-field photo-CIDNP of F10T. This model provides mixing mechanism of energy-levels and spin-dynamics at low magnetic fields. Photo-CIDNP has been observed even at Earth's magnetic field (∼0.05 mT). These experiments prove F10T to be an excellent model compound establishing the key mechanism of avian-magnetoreception and provide insight into the optimal behaviour of cryptochrome at Earth's magnetic field.

Original languageEnglish
Article number11892
Pages (from-to)11892
Number of pages10
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 19 Sep 2017

Keywords

  • ARABIDOPSIS-THALIANA
  • CHEMICAL COMPASS
  • DEPENDENCE
  • DYNAMIC NUCLEAR-POLARIZATION
  • MAGNETORECEPTION
  • MECHANISM
  • MULTINUCLEAR RADICAL PAIRS
  • NMR
  • PHOTO-CIDNP
  • PHOTOACTIVATION REACTION

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