Luminescent Ag(I) scorpionates based on tris(2-pyridyl)phosphine oxide: Synthesis and cytotoxic activity evaluation

Alexander V. Artem'ev, Julia A. Eremina, Elizaveta V. Lider, Olga V. Antonova, Elena V. Vorontsova, Irina Yu Bagryanskaya

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

First representatives of Ag(I) scorpionates bearing tris(2-pyridyl)phosphine oxide (Py3P[dbnd]O), viz. [Ag(Py3P[dbnd]O)(PPh3)]BF4 (1) and [Ag(Py3P[dbnd]O)(PPh3)]ClO4 (2), have been synthesized and structurally characterized. X-ray diffraction analysis reveals that the silver atom of 1 is coordinated by Py3P[dbnd]O and Ph3P ligands in N,N′,N″-tripodal and P-monodentate fashions, respectively. The both complexes exhibit significant cytotoxic activity (IC50 being from 11 to 14 μM) screened in vitro against human larynx carcinoma (Hep-2) cell lines. The luminescent proprieties of the prepared scorpionates are also discussed.

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalPolyhedron
Volume138
DOIs
Publication statusPublished - 14 Dec 2017

Keywords

  • Cytotoxic activity
  • Luminescence
  • Scorpionates
  • Silver
  • Tris(2-pyridyl)phosphine oxide
  • ANTIMICROBIAL PROPERTIES
  • ADDUCTS
  • COPPER
  • UNSUPPORTED SILVER-GERMANIUM
  • LIGANDS
  • CARBONYL
  • CATALYZED CARBENE INSERTION
  • TRIS(PYRAZOLYL)BORATE
  • DERIVATIVES
  • ETHYLENE COMPLEXES

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