Long-wavelength photoremovable protecting groups: On the way to in vivo application

Aleksey Yu Vorobev; Alexander E. Moskalensky

doi:10.1016/j.csbj.2019.11.007

Long-wavelength photoremovable protecting groups: On the way to in vivo application

Aleksey Yu Vorobev, Alexander E. Moskalensky

Research output: Contribution to journal › Review article

1 Citation (Scopus)

Abstract

Photoremovable protective groups (PPGs) and related “caged” compounds have been recognized as a powerful tool in an arsenal of life science methods. The present review is focused on recent advances in design of “caged” compounds which function in red or near-infrared region. The naive comparison of photon energy with that of organic bond leads to the illusion that long-wavelength activation is possible only for weak chemical bonds like N-N. However, there are different means to overcome this threshold and shift the uncaging functionality into red or near-infrared regions for general organic bonds. We overview these strategies, including the novel photochemical and photophysical mechanisms used in newly developed PPGs, singlet-oxygen-mediated photolysis, and two-photon absorption. Recent advances in science places the infrared-sensitive PPGs to the same usability level as traditional ones, facilitating in vivo application of caged compounds.

Original language	English
Pages (from-to)	27-34
Number of pages	8
Journal	Computational and Structural Biotechnology Journal
Volume	18
DOIs	https://doi.org/10.1016/j.csbj.2019.11.007
Publication status	Published - 2020

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Keywords

caged compounds
long-wavelength excitation
photoremovable protecting groups

Cite this

Vorobev, A. Y., & Moskalensky, A. E. (2020). Long-wavelength photoremovable protecting groups: On the way to in vivo application. Computational and Structural Biotechnology Journal, 18, 27-34. https://doi.org/10.1016/j.csbj.2019.11.007

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10.1016/j.csbj.2019.11.007

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