Abstract
Photoremovable protective groups (PPGs) and related “caged” compounds have been recognized as a powerful tool in an arsenal of life science methods. The present review is focused on recent advances in design of “caged” compounds which function in red or near-infrared region. The naive comparison of photon energy with that of organic bond leads to the illusion that long-wavelength activation is possible only for weak chemical bonds like N-N. However, there are different means to overcome this threshold and shift the uncaging functionality into red or near-infrared regions for general organic bonds. We overview these strategies, including the novel photochemical and photophysical mechanisms used in newly developed PPGs, singlet-oxygen-mediated photolysis, and two-photon absorption. Recent advances in science places the infrared-sensitive PPGs to the same usability level as traditional ones, facilitating in vivo application of caged compounds.
Original language | English |
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Pages (from-to) | 27-34 |
Number of pages | 8 |
Journal | Computational and Structural Biotechnology Journal |
Volume | 18 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- caged compounds
- long-wavelength excitation
- photoremovable protecting groups
- DESIGN
- CHROMOPHORE
- STRATEGY
- LIGHT
- PHOTORELEASE
- REACTIVITY
- CAGING GROUP
- RELEASE
- PLATFORM
- PHOTOACTIVATION