Long-term up-regulation of tyrosine hydroxylase gene expression after neonatal dexamethasone

T. Kalinina, E. Sukhareva, V. Bulygina, D. Lanshakov, K. Egorova, N. Dygalo

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Numerical modeling of flow and transport through fractured crystalline rock was conducted to identify major factors that affect migration of radionuclides from a high-level nuclear waste repository. The study was based on data collected at the Mizunami Underground Research Laboratory (URL) in Japan. Distributions of fracture parameters were used to generate a selected number of DFN realizations. For each realization the DFN was upscaled to a continuum mesh to provide permeability and porosity fields. The upscaled permeability and porosity fields were then used to study flow and transport through the fractured rock in a site-scale domain. For the present study the focus is on the effect of domain size and on upscaling of DFN to a continuum system. Simulation results and analysis on various upscaling and boundary condition assumptions are presented.

Original languageEnglish
Pages (from-to)S166-S167
Number of pages6
JournalEuropean Neuropsychopharmacology
Volume29
DOIs
Publication statusPublished - Dec 2019
Event32nd Congress of the European-College-of-Neuropsychopharmacology (ECNP) - Copenhagen, Denmark
Duration: 7 Sep 201910 Sep 2019

OECD FOS+WOS

  • 3.01.RU NEUROSCIENCES
  • 3.02.RT CLINICAL NEUROLOGY
  • 3.01.TU PHARMACOLOGY & PHARMACY
  • 3.02.VE PSYCHIATRY

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