Isoforms of base excision repair enzymes produced by alternative splicing

Elizaveta O. Boldinova, Rafil F. Khairullin, Alena V. Makarova, Dmitry O. Zharkov

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Transcripts of many enzymes involved in base excision repair (BER) undergo extensive alternative splicing, but functions of the corresponding alternative splice variants remain largely unexplored. In this review, we cover the studies describing the common alternatively spliced isoforms and disease-associated variants of DNA glycosylases, AP-endonuclease 1, and DNA polymerase beta. We also discuss the roles of alternative splicing in the regulation of their expression, catalytic activities, and intracellular transport.

Original languageEnglish
Article number3279
Number of pages22
JournalInternational Journal of Molecular Sciences
Volume20
Issue number13
DOIs
Publication statusPublished - 3 Jul 2019

Keywords

  • Alternative splicing
  • Apurinic/apyrimidinic endonuclease
  • DNA glycosylases
  • DNA polymerase beta
  • apurinic
  • alternative splicing
  • DNA-POLYMERASE-BETA
  • APURINIC APYRIMIDINIC ENDONUCLEASE
  • DIFFERENTIAL INTRACELLULAR-LOCALIZATION
  • apyrimidinic endonuclease
  • DEOXYRIBOSE PHOSPHATE LYASE
  • MESSENGER-RNA
  • GLYCOSYLASE DOMAIN
  • MOLECULAR-CLONING
  • HUMAN URACIL
  • MUTY HOMOLOG HMYH
  • LONG-PATCH REPAIR

OECD FOS+WOS

  • 1.06.CQ BIOCHEMISTRY & MOLECULAR BIOLOGY
  • 1.04 CHEMICAL SCIENCES

Fingerprint

Dive into the research topics of 'Isoforms of base excision repair enzymes produced by alternative splicing'. Together they form a unique fingerprint.

Cite this