Interaction of cold atmospheric plasma jet with bio targets: Different sensitivities of human cell lines

Dm Zakrevsky, E. Yelak, P. Gugin, E. Golubitskaya, O. Troizkaja, O. Koval, S. Vagapov, I. Schweigert

Research output: Contribution to journalConference articlepeer-review

Abstract

Cold atmospheric plasma (CAP) jet device is developed and CAP jet was applied for the treatment of normal and cancer cells. The characteristics of plasma jet consisting of a sequence of cathode directed streamers are studied in the experiment and numerical fluid model simulations. A content of mixture of active radicals and ions due to plasma enhanced chemical reactions is calculated with 0D chemical model near the surface of biotarget. The evolution of spatial distribution of the streamer parameters (electric field, electron and ion density, electron energy) delivered by the streamer to the biotarget is calculated. The results of cell viability analysis of normal cells, HEK 293 (kidney embryonic stem cells) and malignant cells, A431 (skin carcinoma) demonstrate the different sensitivity to the indirect CAP jet treatment.

Original languageEnglish
Article number012153
Number of pages5
JournalJournal of Physics: Conference Series
Volume1393
Issue number1
DOIs
Publication statusPublished - 28 Nov 2019
Event14th International Conference on Gas Discharge Plasmas and Their Applications, GDP 2019 - Tomsk, Russian Federation
Duration: 15 Sep 201921 Sep 2019

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