Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution

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6 Citations (Scopus)

Abstract

By using the time-resolved chemically induced dynamic nuclear polarization technique, we show that the neutral guanosyl radical, G(-H), formed in the reaction of guanosine-5′-monophosphate with a triplet-excited 3,3′,4,4′-tetracarboxy benzophenone in neutral aqueous solution, protonates readily at the N7 position with the formation of a new guanosyl cation radical (G+)'.

Original languageEnglish
Pages (from-to)21262-21266
Number of pages5
JournalPhysical Chemistry Chemical Physics
Volume19
Issue number32
DOIs
Publication statusPublished - 28 Aug 2017

Keywords

  • ELECTRON-REDUCTION POTENTIALS
  • TIME-RESOLVED CIDNP
  • GUANINE OXIDATION
  • PULSE-RADIOLYSIS
  • REDOX CHEMISTRY
  • CELLULAR-DNA
  • DAMAGE
  • SPECTROSCOPY
  • NUCLEOTIDES
  • CATIONS

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