Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

T. O. Abramova; M. A. Ryazanova; E. V. Antonov; O. E. Redina; A. L. Markel

doi:10.7868/S0026898417020021

Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

T. O. Abramova, M. A. Ryazanova, E. V. Antonov, O. E. Redina, A. L. Markel

Physiology Section

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.

Original language	English
Pages (from-to)	442-446
Number of pages	5
Journal	Molekuliarnaia biologiia
Volume	51
Issue number	3
DOIs	https://doi.org/10.7868/S0026898417020021
Publication status	Published - 1 May 2017

Keywords

arterial hypertension
ELISA
ISIAH rat strain
real time PCR
renal medulla
soluble epoxide hydrolase

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10.7868/S0026898417020021

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title = "Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension",

abstract = "The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.",

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author = "Abramova, {T. O.} and Ryazanova, {M. A.} and Antonov, {E. V.} and Redina, {O. E.} and Markel, {A. L.}",

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journal = "Molekulyarnaya Biologiya",

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T1 - Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

AU - Abramova, T. O.

AU - Ryazanova, M. A.

AU - Antonov, E. V.

AU - Redina, O. E.

AU - Markel, A. L.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.

AB - The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.

KW - arterial hypertension

KW - ELISA

KW - ISIAH rat strain

KW - real time PCR

KW - renal medulla

KW - soluble epoxide hydrolase

KW - Animals

KW - Blood Pressure

KW - Disease Models, Animal

KW - Epoxide Hydrolases/biosynthesis

KW - Humans

KW - Hypertension/enzymology

KW - Kidney Medulla/enzymology

KW - Male

KW - Nitric Oxide Synthase/genetics

KW - Nitrogen Oxides/metabolism

KW - Oxidative Stress/genetics

KW - Rats

KW - Stress, Physiological/genetics

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U2 - 10.7868/S0026898417020021

DO - 10.7868/S0026898417020021

M3 - Article

C2 - 28707660

AN - SCOPUS:85032638711

VL - 51

SP - 442

EP - 446

JO - Molekulyarnaya Biologiya

JF - Molekulyarnaya Biologiya

SN - 0026-8984

IS - 3

ER -

Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

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Keywords

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