Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

T. O. Abramova, M. A. Ryazanova, E. V. Antonov, O. E. Redina, A. L. Markel

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalMolecular Biology
Volume51
Issue number3
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • arterial hypertension
  • ELISA
  • ISIAH rat strain
  • real time PCR
  • renal medulla
  • soluble epoxide hydrolase

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