In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells

Y. S. Taskaeva, N. P. Bgatova, R. S. Dossymbekova, A. O. Solovieva, S. M. Miroshnichenko, K. O. Sharipov, Z. B. Tungushbaeva

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29) in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbonate. Induction of autophagy in HCC-29 cells was detected by transmission electron microscopy and immunofluorescence staining. Thus, lithium carbonate produces an antitumor effect by arresting cell cycle in the G2/M-phase and induction of apoptosis and autophagy in HCC-29 cells, which confirms the lithium potential as a promising drug for the treatment of hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)246-250
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume170
Issue number2
DOIs
Publication statusPublished - Dec 2020

Keywords

  • apoptosis
  • autophagy
  • cell cycle
  • hepatocellular carcinoma
  • lithium carbonate (LiCO)

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