Hyperpolarized NMR Spectroscopy: d-DNP, PHIP, and SABRE Techniques

Kirill V. Kovtunov, Ekaterina V. Pokochueva, Oleg G. Salnikov, Samuel F. Cousin, Dennis Kurzbach, Basile Vuichoud, Sami Jannin, Eduard Y. Chekmenev, Boyd M. Goodson, Danila A. Barskiy, Igor V. Koptyug

Research output: Contribution to journalReview articlepeer-review

79 Citations (Scopus)


The intensity of NMR signals can be enhanced by several orders of magnitude by using various techniques for the hyperpolarization of different molecules. Such approaches can overcome the main sensitivity challenges facing modern NMR/magnetic resonance imaging (MRI) techniques, whilst hyperpolarized fluids can also be used in a variety of applications in material science and biomedicine. This Focus Review considers the fundamentals of the preparation of hyperpolarized liquids and gases by using dissolution dynamic nuclear polarization (d-DNP) and parahydrogen-based techniques, such as signal amplification by reversible exchange (SABRE) and parahydrogen-induced polarization (PHIP), in both heterogeneous and homogeneous processes. The various new aspects in the formation and utilization of hyperpolarized fluids, along with the possibility of observing NMR signal enhancement, are described.

Original languageEnglish
Pages (from-to)1857-1871
Number of pages15
JournalChemistry - An Asian Journal
Issue number15
Early online date23 May 2018
Publication statusPublished - 6 Aug 2018


  • biological activity
  • contrast agents
  • hyperpolarization
  • imaging agents
  • NMR spectroscopy

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