How miRNA Structure of Animals Influences Their Biogenesis

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.

Original languageEnglish
Pages (from-to)17-29
Number of pages13
JournalRussian Journal of Genetics
Volume56
Issue number1
DOIs
Publication statusPublished - Jan 2020

Keywords

  • biogenesis
  • epigenetics
  • miRNA
  • mirtron
  • mutation
  • pre-miRNA
  • secondary structure
  • single nucleotide polymorphism
  • MICRORNA BIOGENESIS
  • NUCLEAR EXPORT
  • DICER
  • MESSENGER-RNA
  • NONCODING RNAS
  • DROSHA
  • HNRNP A1
  • PROTEINS
  • PRE-MICRORNA
  • BINDING

Fingerprint Dive into the research topics of 'How miRNA Structure of Animals Influences Their Biogenesis'. Together they form a unique fingerprint.

Cite this