How miRNA Structure of Animals Influences Their Biogenesis

P. S. Vorozheykin; I. I. Titov

doi:10.1134/S1022795420010135

How miRNA Structure of Animals Influences Their Biogenesis

P. S. Vorozheykin, I. I. Titov

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.

Original language	English
Pages (from-to)	17-29
Number of pages	13
Journal	Russian Journal of Genetics
Volume	56
Issue number	1
DOIs	https://doi.org/10.1134/S1022795420010135
Publication status	Published - Jan 2020

Keywords

biogenesis
epigenetics
miRNA
mirtron
mutation
pre-miRNA
secondary structure
single nucleotide polymorphism
MICRORNA BIOGENESIS
NUCLEAR EXPORT
DICER
MESSENGER-RNA
NONCODING RNAS
DROSHA
HNRNP A1
PROTEINS
PRE-MICRORNA
BINDING

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title = "How miRNA Structure of Animals Influences Their Biogenesis",

abstract = "MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.",

keywords = "biogenesis, epigenetics, miRNA, mirtron, mutation, pre-miRNA, secondary structure, single nucleotide polymorphism, MICRORNA BIOGENESIS, NUCLEAR EXPORT, DICER, MESSENGER-RNA, NONCODING RNAS, DROSHA, HNRNP A1, PROTEINS, PRE-MICRORNA, BINDING",

author = "Vorozheykin, {P. S.} and Titov, {I. I.}",

note = "Publisher Copyright: {\textcopyright} 2020, Pleiades Publishing, Inc.",

year = "2020",

month = jan,

doi = "10.1134/S1022795420010135",

language = "English",

volume = "56",

pages = "17--29",

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T1 - How miRNA Structure of Animals Influences Their Biogenesis

AU - Vorozheykin, P. S.

AU - Titov, I. I.

PY - 2020/1

Y1 - 2020/1

N2 - MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.

AB - MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.

KW - biogenesis

KW - epigenetics

KW - miRNA

KW - mirtron

KW - mutation

KW - pre-miRNA

KW - secondary structure

KW - single nucleotide polymorphism

KW - MICRORNA BIOGENESIS

KW - NUCLEAR EXPORT

KW - DICER

KW - MESSENGER-RNA

KW - NONCODING RNAS

KW - DROSHA

KW - HNRNP A1

KW - PROTEINS

KW - PRE-MICRORNA

KW - BINDING

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U2 - 10.1134/S1022795420010135

DO - 10.1134/S1022795420010135

M3 - Review article

AN - SCOPUS:85079497188

VL - 56

SP - 17

EP - 29

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 1

ER -

How miRNA Structure of Animals Influences Their Biogenesis

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Keywords

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