Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications

Oleg G. Salnikov, Alexandra Svyatova, Larisa M. Kovtunova, Nikita V. Chukanov, Valerii I. Bukhtiyarov, Kirill V. Kovtunov, Eduard Y. Chekmenev, Igor V. Koptyug

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Magnetic resonance imaging (MRI) with the use of hyperpolarized gases as contrast agents provides valuable information on lungs structure and function. While the technology of 129Xe hyperpolarization for clinical MRI research is well developed, it requires the expensive equipment for production and detection of hyperpolarized 129Xe. Herein we present the 1H hyperpolarization of diethyl ether vapor that can be imaged on any clinical MRI scanner. 1H nuclear spin polarization of up to 1.3 % was achieved using heterogeneous hydrogenation of ethyl vinyl ether with parahydrogen over Rh/TiO2 catalyst. Liquefaction of diethyl ether vapor proceeds with partial preservation of hyperpolarization and prolongs its lifetime by ≈10 times. The proof-of-principle 2D 1H MRI of hyperpolarized diethyl ether was demonstrated with 0.1×1.1 mm2 spatial and 120 ms temporal resolution. The long history of use of diethyl ether for anesthesia is expected to facilitate the clinical translation of the presented approach.

Original languageEnglish
Pages (from-to)1316-1322
Number of pages7
JournalChemistry - A European Journal
Volume27
Issue number4
Early online date3 Sep 2020
DOIs
Publication statusPublished - 18 Jan 2021

Keywords

  • diethyl ether
  • hyperpolarization
  • imaging agents
  • NMR spectroscopy
  • parahydrogen-induced polarization
  • GASES
  • PARA-HYDROGEN
  • NMR SIGNAL ENHANCEMENT
  • MRI
  • RELAXATION
  • PROPANE
  • LIVED SPIN STATES

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