Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals

Kirill V. Kovtunov, Larisa M. Kovtunova, Max E. Gemeinhardt, Andrey V. Bukhtiyarov, Jonathan Gesiorski, Valerii I. Bukhtiyarov, Eduard Y. Chekmenev, Igor V. Koptyug, Boyd M. Goodson

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of 15N NMR signals in 15N-pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.

Original languageEnglish
Pages (from-to)10433-10437
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number35
DOIs
Publication statusPublished - 21 Aug 2017

Keywords

  • het-SABRE
  • heterogeneous catalysis
  • heteronuclei
  • hyperpolarization
  • parahydrogen
  • Magnetic Resonance Spectroscopy
  • Organometallic Compounds/chemistry
  • Catalysis
  • Hydrogen/chemistry
  • Nitrogen Isotopes
  • REVERSIBLE EXCHANGE SABRE
  • CATALYST
  • HYDROGEN-INDUCED POLARIZATION
  • HIGH MAGNETIC-FIELD
  • NUCLEAR-SPIN HYPERPOLARIZATION
  • AMPLIFICATION
  • RESONANCE
  • PARAHYDROGEN-INDUCED POLARIZATION
  • IN-SITU
  • STATE NMR

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