Native gold and PGM from NW Kuznetsk Alatau (NWKA) (South Siberia, Russia) have been investigated. Applying the complex of advanced analytical, geo-chemical, and statistical techniques permits determination of motherlode types of noble mineralization (NM). For gold, it is mineralization of three types: 1 – the gold-sulfide-quartz type associated with dykes of the basic composition and fault-line zones (2), as well as the gold-skarn type (3). For PGM it is mineralization of the Ural-Alaskan (1) and the ophiolitic (2) types, as well as multicomponent alloys associated with layered intrusions (3). The presence of rims and inclusions is indicative of postmagmatic transformations of the minerals. In the meantime, Au and PGM from NW Kuznetsk Alatau placers retain genetic traits of motherlodes.