Genome reorganization during erythroid differentiation

Anastasia Ryzhkova, Nariman Battulin

Research output: Contribution to journalReview articlepeer-review

Abstract

Hematopoiesis is a convenient model to study how chromatin dynamics plays a decisive role in regulation of cell fate. During erythropoiesis a population of stem and progenitor cells becomes increasingly lineage restricted, giving rise to terminally differentiated progeny. The concerted action of transcription factors and epigenetic modifiers leads to a silencing of the multipotent transcriptome and activation of the transcriptional program that controls terminal differentiation. This article reviews some aspects of the biology of red blood cells production with the focus on the extensive chromatin reorganization during differentiation.

Original languageEnglish
Article number1012
JournalGenes
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2021

Keywords

  • 3D genomics
  • Chromatin organization
  • Erythroid differentiation
  • TADs

OECD FOS+WOS

  • 3.02 CLINICAL MEDICINE
  • 1.06 BIOLOGICAL SCIENCES
  • 1.06.KM GENETICS & HEREDITY

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