Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype

Andrey D. Manakhov, Maria Yu Mintseva, Igor A. Andreev, Lev I. Uralsky, Tatiana V. Andreeva, Oleg V. Trapezov, Evgeny I. Rogaev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.

Original languageEnglish
Article number15876
Number of pages6
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Dec 2020

Keywords

  • RAB38

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