Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension

O. E. Redina, V. A. Devyatkin, N. I. Ershov, A. L. Markel

Research output: Contribution to journalArticlepeer-review

Abstract

The paper analyzes the distribution of polymorphic loci in rats of different hypertensive strains. When analyzing the transcribed loci of ISIAH rats and the corresponding loci of 11 other hypertensive strains/substrains of rats, the maximum frequency of occurrence of identical SNPs in different strains was 0.58 (i.e., in 7 of 12 hypertensive strains/substrains). The analysis of the genomic sequences of 11 hypertensive strains/substrains of rats, which model different forms of arterial hypertension, also did not reveal a single SNP common to all 11 hypertensive strains/substrains of rats taken in the analysis. Analysis of experimental data suggests that hypertension is a genetically heterogeneous disease.

Original languageEnglish
Pages (from-to)213-225
Number of pages13
JournalRussian Journal of Genetics
Volume56
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • arterial hypertension
  • genetic heterogeneity
  • polymorphism
  • strains of hypertensive rats
  • OBESITY
  • VARIANTS
  • MODELS
  • DRUG DISCOVERY
  • DISEASE
  • BARDET-BIEDL-SYNDROME
  • GENOME-WIDE ASSOCIATION

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