Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations

Kristiina Tambets, Bayazit Yunusbayev, Georgi Hudjashov, Anne Mai Ilumäe, Siiri Rootsi, Terhi Honkola, Outi Vesakoski, Quentin Atkinson, Pontus Skoglund, Alena Kushniarevich, Sergey Litvinov, Maere Reidla, Ene Metspalu, Lehti Saag, Timo Rantanen, Monika Karmin, Jüri Parik, Sergey I. Zhadanov, Marina Gubina, Larisa D. DambaMarina Bermisheva, Tuuli Reisberg, Khadizhat Dibirova, Irina Evseeva, Mari Nelis, Janis Klovins, Andres Metspalu, Tõnu Esko, Oleg Balanovsky, Elena Balanovska, Elza K. Khusnutdinova, Ludmila P. Osipova, Mikhail Voevoda, Richard Villems, Toomas Kivisild, Mait Metspalu

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Background: The genetic origins of Uralic speakers from across a vast territory in the temperate zone of North Eurasia have remained elusive. Previous studies have shown contrasting proportions of Eastern and Western Eurasian ancestry in their mitochondrial and Y chromosomal gene pools. While the maternal lineages reflect by and large the geographic background of a given Uralic-speaking population, the frequency of Y chromosomes of Eastern Eurasian origin is distinctively high among European Uralic speakers. The autosomal variation of Uralic speakers, however, has not yet been studied comprehensively. Results: Here, we present a genome-wide analysis of 15 Uralic-speaking populations which cover all main groups of the linguistic family. We show that contemporary Uralic speakers are genetically very similar to their local geographical neighbours. However, when studying relationships among geographically distant populations, we find that most of the Uralic speakers and some of their neighbours share a genetic component of possibly Siberian origin. Additionally, we show that most Uralic speakers share significantly more genomic segments identity-by-descent with each other than with geographically equidistant speakers of other languages. We find that correlated genome-wide genetic and lexical distances among Uralic speakers suggest co-dispersion of genes and languages. Yet, we do not find long-range genetic ties between Estonians and Hungarians with their linguistic sisters that would distinguish them from their non-Uralic-speaking neighbours. Conclusions: We show that most Uralic speakers share a distinct ancestry component of likely Siberian origin, which suggests that the spread of Uralic languages involved at least some demic component.

Original languageEnglish
Article number139
Pages (from-to)139
Number of pages20
JournalGenome Biology
Volume19
Issue number1
DOIs
Publication statusPublished - 21 Sep 2018

Keywords

  • Genome-wide analysis
  • Haplotype analysis
  • IBD-segments
  • Population genetics
  • Uralic languages
  • European Continental Ancestry Group/genetics
  • Demography
  • Genes
  • Humans
  • Genetic Variation
  • Asian Continental Ancestry Group/genetics
  • Linguistics
  • Genome, Human
  • Population Dynamics
  • REGRESSION
  • WEST
  • PATTERNS
  • ADMIXTURE
  • INFERENCE
  • MITOCHONDRIAL-DNA
  • ANCESTRY
  • CHROMOSOME HAPLOGROUP-N
  • DIVERSITY
  • SELECTION

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