Generation of three Duchenne muscular dystrophy patient-derived induced pluripotent stem cell (iPSC) lines ICGi002-A, ICGi002-B and ICGi002-C

K. R. Valetdinova, M. A. Maretina, Y. V. Vyatkin, M. P. Perepelkina, A. A. Egorova, V. S. Baranov, A. V. Kiselev, P. M. Gershovich, S. M. Zakian

Research output: Contribution to journalArticlepeer-review

Abstract

Duchenne muscular dystrophy (DMD) is a severe and rapidly progressive hereditary muscular disease with X-linked recessive inheritance, occurring mainly in males. A complete loss of dystrophin resulted from out-of-frame deletion mutations in the DMD gene leads to Duchenne muscular dystrophy. DMD induced pluripotent stem cells (iPSCs) are a suitable cell model to study muscle development and disease mechanisms underlying muscular dystrophy and to screen novel compounds with potential therapeutic effects. We generated iPSCs from a DMD patient using non-integrating episomal plasmid vectors. The obtained iPSC lines showed ESC-like morphology, expression pluripotency markers, displayed a normal karyotype and possessed trilineage differentiation potential.

Original languageEnglish
Article number101941
Number of pages5
JournalStem Cell Research
Volume48
Early online date3 Aug 2020
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • BLOOD

Fingerprint

Dive into the research topics of 'Generation of three Duchenne muscular dystrophy patient-derived induced pluripotent stem cell (iPSC) lines ICGi002-A, ICGi002-B and ICGi002-C'. Together they form a unique fingerprint.

Cite this