Generation of four iPSC lines from two siblings with a microdeletion at the CNTN6 gene and intellectual disability

T. A. Shnaider, I. E. Pristyazhnyuk, A. G. Menzorov, N. M. Matveeva, T. V. Nikitina, A. A. Khabarova, N. A. Skryabin, A. A. Kashevarova, M. E. Lopatkina, L. P. Nazarenko, I. N. Lebedev, O. L. Serov

Research output: Contribution to journalArticlepeer-review

Abstract

The human induced pluripotent stem cell (iPSC) lines, ICGi009-A, ICGi009-B, ICGi013-A and ICGi013-B, were generated from skin fibroblasts of two siblings with intellectual disability. Both patients were carriers of CNTN6 gene microdeletion (Kashevarova et al., 2014). iPSC lines have normal karyotype, express pluripotency markers, are able to differentiate in vitro into derivatives of all three germ layers and represent a unique tool to study neurodevelopmental disorders.

Original languageEnglish
Article number101591
Number of pages5
JournalStem Cell Research
Volume41
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • STEM-CELLS

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