Generation of a spinal muscular atrophy type III patient-specific induced pluripotent stem cell line ICGi003-A

V. S. Ovechkina, M. A. Maretina, A. A. Egorova, V. S. Baranov, A. V. Kiselev, S. M. Zakian, K. R. Valetdinova

Research output: Contribution to journalArticlepeer-review

Abstract

Spinal muscular atrophy (SMA) is a genetic disease, which characterized by the degeneration of motor neurons in the spinal cord and further striated muscle atrophy. The research of the processes in diseased neurons is complicated due to the impossibility of obtaining them safely from patients. Thus, we generated SMA type III induced pluripotent stem cell lines via using non-integrated episomal plasmid vectors. The resulting cell line expresses the major pluripotency markers and can differentiate in vitro into derivatives of three germ layers. The iPSC line can be used for further studies by providing in vitro the relevant cell types.

Original languageEnglish
Article number101938
Pages (from-to)101938
Number of pages4
JournalStem Cell Research
Volume48
Early online date3 Aug 2020
DOIs
Publication statusPublished - 1 Oct 2020

OECD FOS+WOS

  • 1.06.DR CELL BIOLOGY
  • 2.08.DB BIOTECHNOLOGY & APPLIED MICROBIOLOGY

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