Functional polymorphism rs1024611 in the MCP1 gene is associated with the risk of varicose veins of lower extremities

Alexandra S. Shadrina, Mariya A. Smetanina, Kseniya S. Sevost'ianova, Evgenii I. Seliverstov, Evgeny A. Ilyukhin, Elena N. Voronina, Igor A. Zolotukhin, Maxim L. Filipenko

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Objective Monocyte chemoattractant protein 1 (MCP-1) is a chemokine responsible for monocyte, basophil, and T-lymphocyte attraction. Polymorphism rs1024611 located in the regulatory region of the MCP1 gene has previously been shown to be associated with increased MCP-1 production. In our study, we aimed to examine the association of rs1024611 with the risk of primary varicose veins (PVVs) of lower extremities. Methods The case group comprised 470 patients with PVVs, and the control group included 269 individuals without a history of chronic venous disease. All cases and controls were ethnic Russians. Genotypes were determined by real-time polymerase chain reaction allelic discrimination. Association was studied by logistic regression analysis. Results We revealed the association of genotype G/G with the increased risk of PVVs (odds ratio [OR], 1.87; 95% confidence interval [CI], 1.02-3.44; P = .04). In the subgroup analysis, association was revealed only in patients with C2 Clinical, Etiology, Anatomy, and Pathophysiology class (allele G: OR, 1.62 [95% CI, 1.13-2.33; P = .008]; genotype G/G: OR, 3.22 [95% CI, 1.43-7.27; P = .005]), in patients with age at onset of PVVs before 30 years (allele G: OR, 1.41 [95% CI, 1.08-1.85; P = .01]; genotype G/G: OR, 2.35 [95% CI, 1.22-4.55; P = .01]), and in patients who declared no family history (allele G: OR, 1.46 [95% CI, 1.02-2.09; P = .04]; genotype G/G: OR, 2.50 [95% CI, 1.11-5.63; P = .03]). Conclusions Our results provide evidence for MCP-1 involvement in the development of PVVs and indicate that inflammation could be implicated in the pathogenesis of this condition.

    Original languageEnglish
    Pages (from-to)561-566
    Number of pages6
    JournalJournal of Vascular Surgery: Venous and Lymphatic Disorders
    Volume5
    Issue number4
    DOIs
    Publication statusPublished - 1 Jul 2017

    Keywords

    • MONOCYTE CHEMOATTRACTANT PROTEIN-1
    • REGULATORY REGION
    • MYOCARDIAL-INFARCTION
    • DISEASE
    • EXPRESSION
    • ALLELE
    • PATHOGENESIS
    • METAANALYSIS
    • CCL2
    • Predictive Value of Tests
    • Humans
    • Middle Aged
    • Male
    • Case-Control Studies
    • Russia
    • Sensitivity and Specificity
    • Aged, 80 and over
    • Adult
    • Biomarkers/blood
    • Female
    • Chemokine CCL2/blood
    • Genetic Predisposition to Disease
    • Risk Factors
    • Hospitals, University
    • Genotype
    • Varicose Veins/diagnosis
    • Adolescent
    • Alleles
    • Lower Extremity
    • Aged
    • Polymorphism, Single Nucleotide

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