From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis

Ekaterina V. Svezhentseva, Yuri A. Vorotnikov, Anastasiya O. Solovieva, Tatiana N. Pozmogova, Ilia V. Eltsov, Anton A. Ivanov, Darya V. Evtushok, Svetlana M. Miroshnichenko, Vadim V. Yanshole, Charlotte J. Eling, Ali M. Adawi, Jean Sebastien G. Bouillard, Natalia V. Kuratieva, Maria S. Fufaeva, Lidiya V. Shestopalova, Yuri V. Mironov, Olga A. Efremova, Michael A. Shestopalov

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.

Original languageEnglish
Pages (from-to)17915-17920
Number of pages6
JournalChemistry - A European Journal
Volume24
Issue number68
DOIs
Publication statusPublished - 17 Dec 2018

Keywords

  • cluster compounds
  • cytotoxicity
  • hydrolysis
  • molybdenum
  • tungsten
  • ONE-POT SYNTHESIS
  • ER STRESS
  • ENDOPLASMIC-RETICULUM STRESS
  • OXYGEN
  • NANOPARTICLES
  • POLYSTYRENE
  • COMPLEXES SYNTHESIS
  • HEXANUCLEAR MOLYBDENUM
  • LUMINESCENCE
  • GENERATION
  • Photosensitizing Agents/chemistry
  • Humans
  • Cell Survival/drug effects
  • Photochemical Processes
  • Light
  • Drug Stability
  • Models, Molecular
  • Neoplasms/drug therapy
  • Tungsten/chemistry
  • Molybdenum/chemistry
  • Antineoplastic Agents/chemistry
  • Hep G2 Cells
  • Hydrolysis
  • Cell Line, Tumor

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