Abstract
The objective of this study was to find optimal freeze-drying process parameters to design porous and friable freeze-dried bismuth-potassium-ammonium citrate (FD BPAC) with improved dissolution behavior. The nucleation and melting temperatures of frozen BPAC solution in water and tert-butanol/water co-solvent system were studied with use of thermal analysis. The phases that resulted on cooling were studied by low-temperature powder x-ray diffraction. BPAC formed an amorphous freeze concentrate on cooling and remained amorphous during freeze-drying and subsequent storage. The nucleation of colloidal bismuth subcitrate (CBS) in the FD BPAC and starting BPAC systems in 0.1 M and 0.01 M HCl was studied by dynamic light scattering (DLS) method. The proposed preparation method of FD BPAC can be the basis for design of formulations with enhanced dissolution rate for bismuth-based triple/quadruple therapy, where FD BPAC simultaneously act as a carrier and an active ingredient.
Original language | English |
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Pages (from-to) | 173-179 |
Number of pages | 7 |
Journal | Journal of Dispersion Science and Technology |
Volume | 42 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- Bismuth-potassium-ammonium citrate
- dynamic light scattering
- freeze-drying
- nucleation
- THERAPY
- RESISTANCE
- HELICOBACTER-PYLORI
- LYOPHILIZATION