Fluid flow in an enclosed cavity of rotational bioreactor for bone tissue engineering

P. M. Larionov, V. L. Ganimedov, N. A. Maslov, E. O. Tsibulskaya

Research output: Contribution to journalArticlepeer-review

Abstract

The developed mathematical model was applied for study of fluid dynamics in a rotational bioreactor for bone tissue engineering by in vitro technology. The research goal is finding an optimal mode for rotation ensuring proper cyclic loading from fluid upon the cell-seeded biomaterial. The basis for developing a mathematical model of a bioreactor was a design of rotational type biological reactor used in medical research; the liquid flow is generated through viscosity mechanism due to surface rotation. Mathematical description of flow in a reactor cavity was performed with Navier—Stokes equations. It was assumed that flow regime in the boundary layer is laminar. Numerical algorithm was accomplished using a fluid flow solver “Fluent” in the code package ANSYS-12. Four variants of generating the rotational motion in the reactor cavity were considered. A series of parametric computations was performed for the rotation frequency f in the range 0.05 ≤ f ≤ 0.25 Hz. The paper offers visualization of velocity fields in the vertical plane. The distributions for shear stress and pressure in the working zone of reactor were calculated and analyzed. Simulations demonstrated that a method of fluid rotation by driving the outer cylinder with an offset axis is the best for arranging a cyclic pressure and cyclic shear stress on the biological material.

Original languageEnglish
Pages (from-to)901-909
Number of pages9
JournalThermophysics and Aeromechanics
Volume26
Issue number6
DOIs
Publication statusPublished - 1 Nov 2019

Keywords

  • coaxial cylinders
  • laminar flow
  • mathematical simulation
  • Navier—Stokes equations
  • numerical algorithm
  • rotational bioreactor
  • scaffold
  • shear stress
  • Taylor’s vortices
  • CELLS
  • Taylor's vortices
  • SHEAR-STRESS
  • Navier-Stokes equations

Fingerprint

Dive into the research topics of 'Fluid flow in an enclosed cavity of rotational bioreactor for bone tissue engineering'. Together they form a unique fingerprint.

Cite this