Extracellular microvesicular particles in the pathogenesis of tuberculosis

S. E. Petrenko, Y. A.S.H. Shvarts, S. N. Belogorodtsev

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The review describes main classes of extracellular microvesicular particles, mechanisms of their biogenesis and their potential role in the development of tuberculosis. Special attention is paid to apoptosis of macrophages infected with tuberculous mycobacteria, generation of apoptotic ectosome and involvement of the latter into the formation of anti-tuberculosis immune response. Conclusion: mechanisms of apoptotic blebbing, ectosomes and clearing of these particles possess the potential to become a new tool within pathogenetic therapy of tuberculosis.

    Original languageEnglish
    Pages (from-to)41-51
    Number of pages11
    JournalTuberculosis and Lung Diseases
    Volume97
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2019

    Keywords

    • Apoptosis
    • Apoptotic corpuscles
    • Ectosomes
    • Exosomes
    • Tuberculosis

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