Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution

Dudari B. Burueva, Alexey S. Romanov, Oleg G. Salnikov, Vladimir V. Zhivonitko, Yu Wen Chen, Danila A. Barskiy, Eduard Y. Chekmenev, Dennis W. Hwang, Kirill V. Kovtunov, Igor V. Koptyug

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T1 of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3. Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone-d6 or methanol-d4). The approximate values of the HP decay time for propane dissolved in acetone-d6 are 35.1 and 28.6 s for the CH2 group and the CH3 group, respectively (similar values were obtained for propane dissolved in methanol-d4), which are ∼50 times larger than the gaseous propane T1 value. Furthermore, we show that it is possible to retrieve HP propane from solution to the gas phase with the preservation of hyperpolarization.

Original languageEnglish
Pages (from-to)4481-4487
Number of pages7
JournalJournal of Physical Chemistry C
Volume121
Issue number8
DOIs
Publication statusPublished - 2 Mar 2017

Keywords

  • PARAHYDROGEN-INDUCED POLARIZATION
  • HYDROGEN-INDUCED POLARIZATION
  • LIVED SPIN STATES
  • IN-VIVO
  • HETEROGENEOUS HYDROGENATION
  • MAGNETIC-RESONANCE
  • NMR
  • MRI
  • FIELD
  • ENHANCEMENT

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