Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors

V. P. Nikolin, S. S. Bogachev, N. A. Popova, Yu V. Tornuev, E. V. Vinogradova

Research output: Contribution to journalArticlepeer-review

Abstract

We studied radioprotective effects of a preparation based on yeast RNA and its influence on therapeutic efficiency of ionizing radiation against transplanted tumors. Parenteral administration of yeast RNA preparation to mice in a dose of 10 mg 1 h prior to exposure to ionizing γ-radiation (137Cs) in a lethal dose (LD80/30) increased 30-day survival by 66%; by day 80, 80% of animals survived (vs. 2.5% in the control). Whole-body exposure to ionizing γ-radiation in a dose of 7 Gy significantly increased the mean lifespan of mice with experimental lung metastases or intraperitoneally transplanted leukemia L-1210 by 42 and 20.8%, respectively. RNA preparation injected to the mice with tumors 1 h before irradiation did not affect the therapeutic efficiency of ionizing radiation or significantly potentiated it (in mice with transplanted leukemia L-1210). These results suggest that yeast RNA preparation protects healthy tissues during radiotherapy of malignant tumors.

Original languageEnglish
Pages (from-to)639-642
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume163
Issue number5
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • experimental tumor metastases in the lungs
  • leukemia L-1210
  • radioprotectors
  • radiotherapy
  • yeast RNA preparation
  • EXPOSURE

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