Erythrocytes 3D genome organization in vertebrates

Anastasia Ryzhkova, Alena Taskina, Anna Khabarova, Veniamin Fishman, Nariman Battulin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Generation of mature red blood cells, consisting mainly of hemoglobin, is a remarkable example of coordinated action of various signaling networks. Chromatin condensation is an essential step for terminal erythroid differentiation and subsequent nuclear expulsion in mammals. Here, we profiled 3D genome organization in the blood cells from ten species belonging to different vertebrate classes. Our analysis of contact maps revealed a striking absence of such 3D interaction patterns as loops or TADs in blood cells of all analyzed representatives. We also detect large-scale chromatin rearrangements in blood cells from mammals, birds, reptiles and amphibians: their contact maps display strong second diagonal pattern, representing an increased frequency of long-range contacts, unrelated to TADs or compartments. This pattern is completely atypical for interphase chromosome structure. We confirm that these principles of genome organization are conservative in vertebrate erythroid cells.

Original languageEnglish
Article number4414
JournalScientific Reports
Volume11
Issue number1
DOIs
Publication statusPublished - Feb 2021

OECD FOS+WOS

  • 1.06 BIOLOGICAL SCIENCES

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