Abstract
MicroRNAs are small non-coding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.
Original language | English |
---|---|
Pages (from-to) | 1012-1024 |
Number of pages | 13 |
Journal | Russian Journal of Genetics |
Volume | 56 |
Issue number | 8 |
DOIs |
|
Publication status | Published - 1 Aug 2020 |
Keywords
- miRNA
- pre-miRNA
- secondary structure
- biogenesis
- mirtron
- single nucleotide polymorphism
- mutation
- epigenetics
- MICRORNA BIOGENESIS
- NUCLEAR EXPORT
- PRE-MICRORNA
- NONCODING RNAS
- MESSENGER-RNA
- HNRNP A1
- DICER
- DROSHA
- BINDING
- PROTEINS