Engineering chimeric antigen receptors

S. V. Kulemzin, V. V. Kuznetsova, M. Mamonkin, A. V. Taranin, A. A. Gorchakov

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Chimeric antigen receptors (CARs) are recombinant protein molecules that redirect cytotoxic lymphocytes toward malignant and other target cells. The high feasibility of manufacturing CAR-modified lymphocytes for the therapy of cancer has spurred the development and optimization of new CAR T cells directed against a broad range of target antigens. In this review, we describe the main structural and functional elements constituting a CAR, discuss the roles of these elements in modulating the anti-tumor activity of CAR T cells, and highlight alternative approaches to CAR engineering.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalActa Naturae
Issue number1
Publication statusPublished - 1 Jan 2017


  • Adoptive immunotherapy
  • Cancer
  • Chimeric antigen receptor
  • T cells

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