Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy

S. A. Uspenskii; P. A. Khaptakhanova; A. A. Zaboronok; T. S. Kurkin; O. Yu Volkova; L. V. Mechetina; A. V. Taranin; V. V. Kanygin; Matsumura Akira; S. Yu Taskaev

doi:10.1134/S0012500820030027

Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy

S. A. Uspenskii, P. A. Khaptakhanova, A. A. Zaboronok, T. S. Kurkin, O. Yu Volkova, L. V. Mechetina, A. V. Taranin, V. V. Kanygin, Matsumura Akira, S. Yu Taskaev

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Abstract

A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.

Original language	English
Pages (from-to)	45-48
Number of pages	4
Journal	Doklady Chemistry
Volume	491
Issue number	1
DOIs	https://doi.org/10.1134/S0012500820030027
Publication status	Published - 1 Mar 2020

Keywords

boron nanoparticles
boron neutron capture therapy
cavitation
cytotoxicity
elemental boron
epithermal neutron accelerator
glioma
ultrasonic dispersion

OECD FOS+WOS

1.04 CHEMICAL SCIENCES

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10.1134/S0012500820030027

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Uspenskii, S. A., Khaptakhanova, P. A., Zaboronok, A. A., Kurkin, T. S., Volkova, O. Y., Mechetina, L. V., Taranin, A. V., Kanygin, V. V., Akira, M., & Taskaev, S. Y. (2020). Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy. Doklady Chemistry, 491(1), 45-48. https://doi.org/10.1134/S0012500820030027

Uspenskii, S. A. ; Khaptakhanova, P. A. ; Zaboronok, A. A. ; Kurkin, T. S. ; Volkova, O. Yu ; Mechetina, L. V. ; Taranin, A. V. ; Kanygin, V. V. ; Akira, Matsumura ; Taskaev, S. Yu. / Elemental Boron Nanoparticles : Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy. In: Doklady Chemistry. 2020 ; Vol. 491, No. 1. pp. 45-48.

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title = "Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy",

abstract = "A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.",

keywords = "boron nanoparticles, boron neutron capture therapy, cavitation, cytotoxicity, elemental boron, epithermal neutron accelerator, glioma, ultrasonic dispersion",

author = "Uspenskii, {S. A.} and Khaptakhanova, {P. A.} and Zaboronok, {A. A.} and Kurkin, {T. S.} and Volkova, {O. Yu} and Mechetina, {L. V.} and Taranin, {A. V.} and Kanygin, {V. V.} and Matsumura Akira and Taskaev, {S. Yu}",

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doi = "10.1134/S0012500820030027",

language = "English",

volume = "491",

pages = "45--48",

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Elemental Boron Nanoparticles : Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy. / Uspenskii, S. A.; Khaptakhanova, P. A.; Zaboronok, A. A.; Kurkin, T. S.; Volkova, O. Yu; Mechetina, L. V.; Taranin, A. V.; Kanygin, V. V.; Akira, Matsumura; Taskaev, S. Yu.

In: Doklady Chemistry, Vol. 491, No. 1, 01.03.2020, p. 45-48.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Elemental Boron Nanoparticles

T2 - Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy

AU - Uspenskii, S. A.

AU - Khaptakhanova, P. A.

AU - Zaboronok, A. A.

AU - Kurkin, T. S.

AU - Volkova, O. Yu

AU - Mechetina, L. V.

AU - Taranin, A. V.

AU - Kanygin, V. V.

AU - Akira, Matsumura

AU - Taskaev, S. Yu

PY - 2020/3/1

Y1 - 2020/3/1

N2 - A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.

AB - A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.

KW - boron nanoparticles

KW - boron neutron capture therapy

KW - cavitation

KW - cytotoxicity

KW - elemental boron

KW - epithermal neutron accelerator

KW - glioma

KW - ultrasonic dispersion

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DO - 10.1134/S0012500820030027

M3 - Article

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VL - 491

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EP - 48

JO - Doklady Chemistry

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SN - 0012-5008

IS - 1

ER -

Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy

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Keywords

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