Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy

S. A. Uspenskii, P. A. Khaptakhanova, A. A. Zaboronok, T. S. Kurkin, O. Yu Volkova, L. V. Mechetina, A. V. Taranin, V. V. Kanygin, Matsumura Akira, S. Yu Taskaev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalDoklady Chemistry
Volume491
Issue number1
DOIs
Publication statusPublished - 1 Mar 2020

Keywords

  • boron nanoparticles
  • boron neutron capture therapy
  • cavitation
  • cytotoxicity
  • elemental boron
  • epithermal neutron accelerator
  • glioma
  • ultrasonic dispersion

OECD FOS+WOS

  • 1.04 CHEMICAL SCIENCES

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