Abstract
A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.
Original language | English |
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Pages (from-to) | 45-48 |
Number of pages | 4 |
Journal | Doklady Chemistry |
Volume | 491 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Mar 2020 |
Keywords
- boron nanoparticles
- boron neutron capture therapy
- cavitation
- cytotoxicity
- elemental boron
- epithermal neutron accelerator
- glioma
- ultrasonic dispersion