Electrophilic and oxidative fluorination of aromatic compounds

Pavel A. Zaikin, Gennady I. Borodkin

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

3 Citations (Scopus)

Abstract

Fluoroaromatic compounds play an extremely important role in drug design and diagnostics, especially in positron emission tomography. During the past decade, efficient and environmentally benign methods of fluorination were developed. This chapter covers experimental results published during last decade. Older works will be referenced only when necessary for understanding of the discussed results. Special emphasis will be given to radiofluorination. Also, some aspects of the fluorination of organoelement compounds will be covered.

Original languageEnglish
Title of host publicationLate-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates
PublisherElsevier
Pages105-135
Number of pages31
ISBN (Electronic)9780128129586
ISBN (Print)978-0-12-812958-6
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Aromatic compounds
  • Electrophilic fluorination
  • Nf-reagents
  • Oxidative fluorination
  • Positron emission tomography
  • ELECTROCHEMICAL FLUORINATION
  • SELECTIVE FLUORINATION
  • N-FLUOROBENZENESULFONIMIDE
  • MEDICINAL CHEMISTRY
  • ANODIC FLUORINATION
  • HYPERVALENT IODINE
  • C-H FLUORINATION
  • ELEMENTAL FLUORINE
  • ORGANIC-COMPOUNDS
  • LATE-STAGE FLUORINATION

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