Effects of the Atypical Antipsychotic Quetiapine on the Immune Response in Aggressive Mice in a Model of Social Stress

G. V. Idova, M. A. Cheido, E. N. Zhukova, E. L. Al’perina

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic (10 days)administration of the atypical antipsychotic quetiapine (3.75 mg/kg) induced significant suppression of the IgM immune response in mice with aggressive behavior formed as a result of prolonged (14 days in CBA mice, 20 days in C57BL/6J mice) confrontations and in animals with unaltered psychoemotional status. The immunosuppressive action of quetiapine was independent of the genotype of the mice and the route (i.p. or p.o.) and scheme (single or repeated) of administration. Possible serotonin (5-HT) and dopamine (DA) receptor mechanisms of the immunomodulatory effects of quetiapine are discussed.

Original languageEnglish
Pages (from-to)506-510
Number of pages5
JournalNeuroscience and Behavioral Physiology
Volume48
Issue number4
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • 5-HT receptors
  • aggressive behavior
  • IgM immune response
  • quetiapine
  • social stress

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