Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice

Research output: Contribution to journalArticlepeer-review

Abstract

Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, in relation to subcutaneous xenografts of human colon adenocarcinoma SW-620 in SCID mice. Utilization of BNCT with boronоphenylalanine (BPA) and sodium borocaptate (BSH), which were injected intravenously into the retroorbital sinus, resulted in a significant decrease in tumor volumes compared to the control group (no radiation).

Original languageEnglish
Pages (from-to)359-363
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume172
Issue number3
DOIs
Publication statusPublished - Jan 2022

Keywords

  • accelerator based epithermal neutron source
  • boron neutron capture therapy
  • boronоphenylalanine
  • human colorectal adenocarcinoma
  • sodium borocaptate

OECD FOS+WOS

  • 3.01.QA MEDICINE, RESEARCH & EXPERIMENTAL
  • 1.06 BIOLOGICAL SCIENCES

Fingerprint

Dive into the research topics of 'Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice'. Together they form a unique fingerprint.

Cite this