Effect of type 1 diabetes mellitus of different duration on the Willis' circle angioarchitectonics

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Abstract

The vascular system of the brain has a complex structure. One of the most important of its parts is the Willis' circle. In the article, we consider the effect of type 1 diabetes mellitus duration 1 and 2 months on the angiarchitectonics of the Willis' circle of NODSCID mice. MRA data was supplemented with mathematical post-processing. On the basis of the 3D images of blood vessels of the brain, their geometrical characteristics - angles of the vessels and the area of their orthogonal cross-sections were measured. Based on the data obtained, the following conclusions can be made: for animals with a disease development period of 1 month, there are no significant differences in the architectonics of the Willis' circle. However, with the duration of the disease for 2 months, diabetes begins to affect the architectonics of major vessels of the brain.

Original languageEnglish
Title of host publication19th International Conference on the Methods of Aerophysical Research, ICMAR 2018
Editors Fomin
PublisherAmerican Institute of Physics Inc.
Number of pages5
Volume2027
ISBN (Electronic)9780735417472
DOIs
Publication statusPublished - 2 Nov 2018
Event19th International Conference on the Methods of Aerophysical Research, ICMAR 2018 - Akademgorodok, Novosibirsk, Russian Federation
Duration: 13 Aug 201819 Aug 2018

Publication series

NameAIP Conference Proceedings
PublisherAMER INST PHYSICS
Volume2027
ISSN (Print)0094-243X

Conference

Conference19th International Conference on the Methods of Aerophysical Research, ICMAR 2018
CountryRussian Federation
CityAkademgorodok, Novosibirsk
Period13.08.201819.08.2018

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