Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin

L. V. Yanshole, V. V. Yanshole, O. A. Snytnikova, A. Zh Fursova, N. G. Kolosova, Yu P. Tsentalovich, R. Z. Sagdeev

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.

Translated title of the contributionВлияние глазных капель SkQ1 на метаболомный состав крысиного хрусталика и на шаперонную активность альфа-кристаллина
Original languageEnglish
Article number21
Pages (from-to)341-345
Number of pages5
JournalDoklady Biochemistry and Biophysics
Volume464
Issue number1
DOIs
Publication statusPublished - 1 Sep 2015

OECD FOS+WOS

  • 1.06 BIOLOGICAL SCIENCES
  • 1.04 CHEMICAL SCIENCES

State classification of scientific and technological information

  • 31 CHEMISTRY

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