Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels

P. D. Pravikova, V. Lavrinenko, L. N. Ivanova

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1 Citation (Scopus)

Abstract

We studied the effect of NO synthesis blockade on the hydrouretic function and the state of renal interstitial matrix in WAG rats with normal blood vasopressin level and Brattleboro rats lacking endogenous vasopressin. In WAG rats, impaired osmotic concentration accompanied by an increase in the content of histochemically detectable glycosaminoglycans in the inner medullary interstitium was observed under conditions of NO synthesis blockade. In Brattleboro rats, NO synthesis inhibition, on the contrary, induced an antidiuretic response without significant changes in the renal extracellular matrix. These findings attested to a significant influence of NO on the urine concentration process. Morphofunctional changes in the kidneys under conditions of NO synthesis blockade are determined by blood vasopressin level.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume167
Issue number2
DOIs
Publication statusPublished - 15 Jun 2019

Keywords

  • concentrating function
  • hyaluronan
  • kidney
  • nitric oxide
  • vasopressin

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