Effect of ball-milling on the formation of betulin and betulin diacetate composites with polyethylene glycol

Tatyana P. Shakhtshneider, Mikhail A. Mikhailenko, Valeri A. Drebushchak, Tatiana N. Drebushchak, Yuri N. Malyard, Svetlana A. Kuznetsova

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Betulin and betulin diacetate (BDA) composites with polyethylene glycol (PEG) were obtained by ball-milling. In case of betulin - PEG mixtures, there was almost complete amorphization under ball-milling. On the contrary, there were no significant changes in the intensity of the reflections in the powder X-ray diffraction patterns for ball-milled mixtures of BDA with PEG. Dissolution of BDA in PEG melts formed at the contacts of particles under collisions with milling bodies leading to crystallization of the drug was suggested. An opportunity to dissolve BDA crystals in PEG melt followed by their crystallization was proven by DSC and hot stage optical microscopic observation.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalMaterials Today: Proceedings
Publication statusPublished - 1 Jan 2019
Event5th International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT) - Novosibirsk
Duration: 25 Jun 201828 Jun 2018


  • betulin
  • betulin diacetate
  • PEG
  • ball-milling
  • composite formation
  • amorphization
  • melting
  • crystallization
  • Betulin
  • Melting
  • Ball-milling
  • Amorphization
  • Crystallization
  • Betulin diacetate
  • Composite formation

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